{
  "_id": "6a1f17b4b401979e7341eb8c",
  "Package": "hbim",
  "Type": "Package",
  "Title": "Hill/Bliss Independence Model for Combination Vaccines",
  "Version": "1.1.2",
  "Date": "2023-08-24",
  "Author": "Michael P. Fay",
  "Maintainer": "Michael P. Fay <mfay@niaid.nih.gov>",
  "Description": "Calculate expected relative risk and proportion protected\nassuming normally distributed log10 transformed antibody dose\nfor a several component vaccine. Uses Hill models for each\ncomponent which are combined under Bliss independence. See Saul\nand Fay, 2007 <DOI:10.1371/journal.pone.0000850>.",
  "License": "GPL-3",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-17 05:56:12 UTC",
    "User": "root"
  },
  "Repository": "https://michaelfay-niaid.r-universe.dev",
  "Date/Publication": "2023-08-24 16:35:17 UTC",
  "RemoteUrl": "https://github.com/cran/hbim",
  "RemoteRef": "HEAD",
  "RemoteSha": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
  "MD5sum": "95324bc600a92fbea37521c289dc3eed",
  "_user": "michaelfay-niaid",
  "_type": "src",
  "_file": "hbim_1.1.2.tar.gz",
  "_fileid": "97839388182e6743ab2f607feff15e694871aa2f4cc33f85496c7325ee761219",
  "_filesize": 523387,
  "_sha256": "97839388182e6743ab2f607feff15e694871aa2f4cc33f85496c7325ee761219",
  "_created": "2026-05-17T05:56:12.000Z",
  "_published": "2026-06-02T17:49:40.849Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 79136010625,
      "time": 110,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7039804434"
    },
    {
      "job": 79136010847,
      "time": 98,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7039803322"
    },
    {
      "job": 79136011556,
      "time": 88,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7039801963"
    },
    {
      "job": 79136010894,
      "time": 106,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7039803930"
    },
    {
      "job": 79136010001,
      "time": 154,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7039792464"
    },
    {
      "job": 79136010327,
      "time": 90,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7365584249"
    },
    {
      "job": 79136010776,
      "time": 67,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7039799955"
    },
    {
      "job": 79136011481,
      "time": 58,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7039798893"
    },
    {
      "job": 79136011068,
      "time": 65,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7039799559"
    }
  ],
  "_buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/cran/hbim",
  "_commit": {
    "id": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
    "author": "Michael P. Fay <mfay@niaid.nih.gov>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 1.1.2\n",
    "time": 1692894917
  },
  "_maintainer": {
    "name": "Michael P. Fay",
    "email": "mfay@niaid.nih.gov",
    "login": "michaelfay-niaid",
    "description": "I am a biostatistician and maintain several R packages,",
    "uuid": 212777592
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 2.5.0",
      "role": "Depends"
    },
    {
      "package": "stats",
      "role": "Depends"
    },
    {
      "package": "mvtnorm",
      "role": "Depends"
    }
  ],
  "_owner": "cran",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 0,
  "_contributors": [
    {
      "user": "michaelfay-niaid",
      "count": 6,
      "uuid": 212777592
    }
  ],
  "_userbio": {
    "uuid": 212777592,
    "type": "user",
    "name": "Michael P Fay",
    "description": "I am a biostatistician and maintain several R packages,"
  },
  "_downloads": {
    "count": 234,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/hbim"
  },
  "_mentions": 2,
  "_searchresults": 8,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/hbim.html",
    "manual.pdf"
  ],
  "_realowner": "michaelfay-niaid",
  "_cranurl": false,
  "_releases": [
    {
      "version": "0.9.5-1",
      "date": "2007-09-13"
    },
    {
      "version": "1.0.1",
      "date": "2010-04-12"
    },
    {
      "version": "1.0.2",
      "date": "2012-03-21"
    },
    {
      "version": "1.0.3",
      "date": "2014-03-05"
    },
    {
      "version": "1.1",
      "date": "2022-05-09"
    },
    {
      "version": "1.1.2",
      "date": "2023-08-24"
    }
  ],
  "_exports": [
    "calc.foldrange",
    "eff.mu",
    "eff.rho",
    "eff.sigma",
    "equiv.ab",
    "equiv.increase",
    "hbpp",
    "hbpp.integrate1",
    "hbpp.integrate2",
    "hbpp.integrate3",
    "hbpp.simulate",
    "hbrr",
    "hbrr.integrate1",
    "hbrr.integrate2",
    "hbrr.integrate2.rhoeq1",
    "hbrr.integrate3",
    "hbrr.integrate3.rhoeq1",
    "hbrr.simulate",
    "make.v",
    "plotlogm.resp",
    "plotresp.equiv",
    "plotresp.mix",
    "pp.mu",
    "pp.rho",
    "pp.sigma"
  ],
  "_datasets": [
    {
      "name": "deff.mu",
      "title": "HBIM data",
      "object": "deff.mu",
      "file": "deff.mu.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "deff.rho",
      "title": "HBIM data",
      "object": "deff.rho",
      "file": "deff.rho.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "deff.sigma",
      "title": "HBIM data",
      "object": "deff.sigma",
      "file": "deff.sigma.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "dpp.mu",
      "title": "HBIM data",
      "object": "dpp.mu",
      "file": "dpp.mu.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "dpp.rho",
      "title": "HBIM data",
      "object": "dpp.rho",
      "file": "dpp.rho.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "dpp.sigma",
      "title": "HBIM data",
      "object": "dpp.sigma",
      "file": "dpp.sigma.rda",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "irdata",
      "title": "Immune Response data",
      "object": "irdata",
      "file": "irdata.rda",
      "class": [
        "data.frame"
      ],
      "fields": [
        "RecordNum",
        "Old.Reference",
        "Reference",
        "Vaccine.and.trial.group",
        "Carrier.for.conjugate.vaccines",
        "Age.in.yrs.at.first.vaccination",
        "Dose.schedule.in.weeks",
        "Num.Immunizations",
        "Endpoint.in.weeks.after.first.vaccine",
        "Antigen",
        "Units",
        "GMT",
        "GMT.95.pct.interval.low.limit",
        "GMT.95.pct.interval.high.limit",
        "n",
        "Fold.Range"
      ],
      "rows": 574,
      "table": true,
      "tojson": true
    },
    {
      "name": "refs",
      "title": "Reference list",
      "object": "refs",
      "file": "refs.rda",
      "class": [
        "factor"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "hbim-package",
      "title": "Hill/Bliss Independence Model for Multicomponent Vaccines",
      "topics": [
        "hbim-package",
        "hbim"
      ]
    },
    {
      "page": "calc.foldrange",
      "title": "Calculate stadard error and fold-range from confidence interval",
      "topics": [
        "calc.foldrange"
      ]
    },
    {
      "page": "deff.sigma",
      "title": "HBIM data",
      "topics": [
        "deff.mu",
        "deff.rho",
        "deff.sigma",
        "dpp.mu",
        "dpp.rho",
        "dpp.sigma"
      ]
    },
    {
      "page": "eff.mu",
      "title": "Create data sets for plots",
      "topics": [
        "eff.mu",
        "eff.rho",
        "eff.sigma",
        "pp.mu",
        "pp.rho",
        "pp.sigma"
      ]
    },
    {
      "page": "equiv.ab",
      "title": "Equivalent antibody calculations by Linear Interpolation",
      "topics": [
        "equiv.ab"
      ]
    },
    {
      "page": "equiv.increase",
      "title": "Calculate equivalent increase from two dose-response curves",
      "topics": [
        "equiv.increase"
      ]
    },
    {
      "page": "hbrr",
      "title": "Calculate expected relative risk or percent protected from Hill model with Bliss Independence",
      "topics": [
        "hbpp",
        "hbrr"
      ]
    },
    {
      "page": "irdata",
      "title": "Immune Response data",
      "topics": [
        "irdata"
      ]
    },
    {
      "page": "make.v",
      "title": "Make Exchangeable Variance Matrix",
      "topics": [
        "make.v"
      ]
    },
    {
      "page": "plotlogm.resp",
      "title": "Plot Hill/Bliss Independence Model Data.",
      "topics": [
        "plotlogm.resp",
        "plotresp.equiv",
        "plotresp.mix"
      ]
    },
    {
      "page": "refs",
      "title": "Reference list",
      "topics": [
        "refs"
      ]
    }
  ],
  "_rundeps": [
    "mvtnorm"
  ],
  "_vignettes": [
    {
      "source": "hbimdetails.Rnw",
      "filename": "hbimdetails.pdf",
      "title": "Details of calculations for \"Multicompent, single target vaccines\"",
      "engine": "utils::Sweave",
      "headings": [],
      "created": "2014-03-05",
      "modified": "2014-03-05",
      "commits": 1
    }
  ],
  "_score": 2.3010299956639813,
  "_indexed": true,
  "_nocasepkg": "hbim",
  "_universes": [
    "michaelfay-niaid"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.1.2",
      "date": "2026-05-17T05:58:00.000Z",
      "distro": "noble",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "50dc5221c3fe44c03e043cb07134ab0c9ceba3082181c367dcf35ae86ab93715",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.1.2",
      "date": "2026-05-17T05:57:53.000Z",
      "distro": "noble",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "f8f85d9d03bcd59b9c78c1f91ba9fa9dfc5b44fef9f741c1af6040d2c3522f3a",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.1.2",
      "date": "2026-05-17T05:57:42.000Z",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "5db0968b360cbb9f89eed3350ddd1269a416562392639674dd59081ff26e5cc1",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.1.2",
      "date": "2026-05-17T05:57:58.000Z",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "d58316903817a1c50723708489c21c138dac43a03b8215e15df211ff7128afff",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.1.2",
      "date": "2026-05-17T05:57:16.000Z",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "fbef6c4946dd8028bac0bb17d2956135c767221bf73f3674d976c3042fdab2bf",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.1.2",
      "date": "2026-05-17T05:57:08.000Z",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "4edae3b026d7c1187667ed0aaf9dc485a0a222e328583ecb8448b583467f55d8",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.1.2",
      "date": "2026-05-17T05:57:13.000Z",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "c07c40abe212106428b4f09e0f9ebd1c33a1fd89dd5569f84b869b33d9d1eb31",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.1.2",
      "date": "2026-06-02T17:49:18.000Z",
      "commit": "9f0c312dc0c58c7ce0e5b2a288a6dd7934b4d353",
      "fileid": "0ee4df7983ff96cdb816bc8356b8f4c21a56cab1986af6fc3514d8f40b9bb8fb",
      "status": "success",
      "buildurl": "https://github.com/r-universe/michaelfay-niaid/actions/runs/25982852710"
    }
  ]
}